2005年9月-2009年7月 ???山東大學(xué)藥學(xué)院， 學(xué)士
2009年9月-2014年7月 ???中科院上海藥物研究所藥物設(shè)計(jì)專業(yè)，博士
2015年2月-2020年7月 ???The Johns Hopkins University School of Medicine，博士后
2020年8月至今?????????中科院廣州生物醫(yī)藥與健康研究院化學(xué)生物學(xué)所，研究員
1.腫瘤轉(zhuǎn)錄異常關(guān)鍵靶標(biāo)的動態(tài)結(jié)構(gòu)-致癌功能關(guān)系研究?
2.靶向致癌表觀遺傳調(diào)節(jié)蛋白和譜系特異性致癌轉(zhuǎn)錄因子的創(chuàng)新藥物發(fā)現(xiàn)?
3.現(xiàn)有表觀遺傳藥物在腫瘤和遺傳性疾病治療中的精準(zhǔn)應(yīng)用
Pharmaceutical Science Advances（PHSA）青年編委
美國癌癥研究協(xié)會(AACR) 會員
2023年? 中科院率先行動高層次人才引進(jìn)計(jì)劃
2022年? 廣東省青年拔尖人才
2019年??美國癌癥研究協(xié)會（AACR）Scholar in Training Award?
2015年??上海市研究生優(yōu)秀學(xué)位論文?
1.Kong X#, Chen J#, Xie W#, Brown S, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann R, Tao Y, Yen R, Topper MJ, Easwaran H, Rothbart SB*, Xia L*, Baylin SB*,?Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties,?Cancer Cell.?2019;35(4):633-648
2.Zhang H#, Xu D#, Huang H#, Jiang H, Hu L, Liu L, Sun G, Gao J, Li Y, Xia C, Chen S, Zhou H, Kong X*, Wang M*, Luo C*, Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase, ACS Chem Biol. 2024;19(4):999-1010.
3.Li P, Xia C, Kong X*, Zhang J*, Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications, Bioorg Chem. 2024;143:106963.
4.Zhu C, Liu J, Ni Y, Chen W, Rong W, Zhang X, Guo C, Kong X*, Tang S*, Synthesis of STM2457, a selective small-molecule inhibitor of METTL3, Tetrahedron Lett. 2024; 141, 155077
5.Li E, Wang K, Zhang B, Guo S , Xiao S , Pan Q , Wang X , Chen W , Wu Y , Xu H, Kong X*, Luo C, Chen S*, Liu B*, Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, J Enzyme Inhib Med Chem. 2022;37(1):1537-55
6.Kong X#, Liu J#, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*,?Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition,?Nucleic Acids Res.?2015;43(9):4381-92
7.Kong X#, Chen L#, Jiao L, Jiang X, Lian F, Lu J, Zhu K, Du D, Liu J, Ding H, Zhang N, Shen J, Zheng M, Chen K, Liu X, Jiang H, Luo C*.?Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2,?J Med Chem.?2014;57(22):9512-21
8.Ye F#,?Kong X#, Zhang H, Liu Y, Shao Z, Jin J, Cai Y, Zhang R, Li L, Zhang YW, Liu YC, Zhang C, Xie W, Yu K, Ding H, Zhao K, Chen S*, Jiang H, Baylin SB*, Luo C*.?Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1,?ACS Chem Biol. 2018;13(3):772-781
9.Zhu M#, Du D#, Hu J, Li L, Liu J, Ding H,?Kong X*, Jiang H, Chen K, Luo C*,?Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors,?Acta Pharmacol Sin.?2018;39(2):302-310?
